Cardiovascular Diseases
Modulation of energy substrate metabolism offers a novel approach for the treatment of various forms of heart disease, including angina pectoris, acute myocardial infarction (heart attack), hypertrophic heart disease, cardiomyopathies and congestive heart failure.

Muscle Efficiency
Modulation of energy substrate metabolism in post- ischemic cardiac and skeletal muscles enhances muscle contractility. Mechanical work, as well as the efficiency of oxygen utilization, is also improved. This is beneficial in all forms of heart disease, as well as in peripheral vascular diseases such as intermittent claudication.

Cardiac Surgery and Angioplasty
Modulation of energy substrate metabolism prevents damage associated with cardiac surgery and improves the recovery of myocardial mechanical function and efficiency of the reperfused post-ischemic heart.

Diabetes and Metabolic Diseases
Alteration of carbohydrate and fatty acid metabolism offers the therapeutic potential for the management of diabetes, as well as other metabolic diseases and their complications.